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ISO722AQ Ioff

Hi
 
ISO7221AQ
 
To "Vcc1 (1 pin) and Vcc2 (8 pin)" in a state in which the power is not supplied,
 If the DC voltage(3.3V or 5V) is applied to the INB (3 pin) and INA (7 pin),
 Do you become a problem?
 
Best regards