I am using a PCA9545APWR to connect a master I2C from controller to four slave devices mostly sensors. When ever I want to connect to a slave, I command the switch to establish a connection with that slave and disconnect all other slaves. So at any time the switch will be connected to only one slave. When all slave are powered on there is no problem. But when a slave is powered off and if I connect to that slave, from that time onwards the I2C switch is not responding (any attempt to configure the I2C switch ends with no acknowledgement). Please assist us to solve this issue.