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I want to know if you are using the TCA6424A? We recommend that you use the A version as the TCA6424 is NRND.
If you configure the pin as an input, but if you want it to be default high, then you will need pull up resistors.
Please read the datasheet. It goes into great detail into how to program the device. If you finish reading the datasheet and still have questions, then by all means please post a specific question.
