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PCA9306: PCA9306 I2C host location

Part Number: PCA9306

Hi Team,

Please advise me the question bellow.

In “Simplified Application Diagram” on PCA9306 datasheet, I2C hos is located on the
Left side of the device (Ref1) and I2C salve device is placed on the right side (Ref2).

Can you place the I2C host on right side (Ref2 High voltage side) and I2C salve devices are
Placed on the left side (Ref1 Low voltage side)?

Are there any reason why I2C host is placed on low voltage side?

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