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TS3USB221: TS3USB221 for I2C

Part Number: TS3USB221

Hi Team

     I have use TS3USB221 for USB switch , but  I need help confirm some question for TS3USB221RSER ( USB MUX switch IC )  We want to use it on new RFQ  and will set it to switching of I2C signal.

Can we use TS3USB221 on I2C bus?
 
thanks.