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Hey Lilian,
For PCA9306 it would be best to have a pull down resistor tied to the EN pin and then tie a GPIO pin from a mcu/FPGA/master to the EN. This way the PCA9306 will be powered off until the master enables it back on.
I would also recommend that GPIO voltage be greater than or atleast equal to the lowest of the two (Vref1 or Vref2).
Thanks,
-Bobby