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TCA9548A: TCA9548A channel powered ON but TCA9548A is powered DOWN

Part Number: TCA9548A

I would like to know if there is any issue with the device TCA9548AMRGER being powered off and the the I2C channels remain powered?

Ie VCC=1.8V and SD3=2.5V, when 1.8V is powered OFF, 2.5V is powered ON

Thanks!