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TCA9539-Q1: Cross current through SDA / SCL ports via pullups

Part Number: TCA9539-Q1
Other Parts Discussed in Thread: TCA9538

Hello,

is there a riskt of cross current when power supply of the TCA9538 and the pull up resistors of the I2C interface aren´t on the same power domain?

Intention is to use several I2C slaves on the same bus like the TCA9538. Due to functional reasons the slaves and the MCU are on a continous power domain and has to be functional any time, but the port expander is supplied with a power domain, which can be switched of. So is there arisk to cross current into the switched power domain, via the pull up resistors?

Best regards

Raphael