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TUSB213: Toggle RSTN in I2C mode

Part Number: TUSB213

Dear Team,

There is a description on the datasheet said :

In order for the TUSB213-Q1 to recognize any change to the AC and DC Boost settings, the RSTN pin must be toggled. This is because the configuration is latched on power up and the inputs are ignored thereafter.

But now my customer is using I2C mode. Do they still need to toggle RSTN after changing register value over I2C?

Thank you.

Jim