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How to select a appropriate TVS?



TVS is common ESD protection component and I have questions regarding it.

1. Some TVS families seems be designed for power lines particularly. Should we select different TVS for power lines and data lines?

2. Sometimes, I see engineers use TVS for USB VBUS and the maximum VRWM (Reverse standoff voltage) is 5.0V. However, the VBUS may exceed 5V. Many USB power supplies provide the 5.1V or 5.2V voltage and the specification of VBUS is 4.75V to 5.25V. I'm wondering If it is a good idea to use the TVS which maximum VRWM is 5.0V for USB VBUS? Or it is better to select the TVS which is with 5.5V or 6.0V VRWM?