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Do you mean SN65HVD10 and MAX3221 share a same wire? It's OK to do so, but please be aware that SN65HVD10 bus pins have -9V to 14V abs max. Theoretically RS-232 signal swing from -15V to 15V. However MAX3221 Dout range is much smaller than that, which works with SN65HVD10. Please let me know if you have more questions.
