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TS5USBA224: Vaudio connected to VBUS - Is this OK?

Part Number: TS5USBA224

We have a battery operated instrument.  In some cases, the internal battery is dead and the user will plug in a USB cable to charge.  In this case VDD (Vaudio) is not present, and we have fried 3 ICs.  since this IC is only used while a USB cable is plugged in, can be connect  Vaudio to VBUS?  Would this cause a problem to the uP when powered and the TS5USBA224 is not?