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TS3USB221A: Swapping D+ and D-

Part Number: TS3USB221A

Are we allowed to swap D+ and D- on the TS3USB221ARSER if we swap them on all the INs and OUTs?  So basically all the D+ pins on the part get connected to D- signals on the PCB and all the D- pins get connected to the D+ signals on the PCB.  This would improve routing, but wasn't sure how "transparent" the part was. It seems like this should work if you just assume it is a basic CMOS mux.

Thanks