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DS100BR410: I2C CS pin

Part Number: DS100BR410
Other Parts Discussed in Thread: TCA9538

On page 10 of the DS100BR410 datasheet it says that in order to talk to other slave devices on the I2C bus, the CS pin needs to be low...does this even apply to chips on the I2C bus with different addresses?

In my design I'm currently using the TCA9538 I2C GPIO Expander to control the CS pin of the DS100BR410. Since the TCA9538 and DS100BR410 are on the same I2C bus, does this mean that once the TCA9538 raises the CS pin, I won't be able to lower CS again because the DS100BR410 will not allow communication with other slaves?