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Hi
Can SN74LVC244A support 50MHz? Thanks.
In Single I/O mode, all signals are unidirectional, and you can use a logic buffer. LVC will probably work. However, for such a low voltage, I suggest to use a family optimized for low voltages like AUC, e.g., SN74AUC17.
In other I/O modes, eSPI has bidirectional signals, and you cannot buffer them.