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SN74LVC1T45-Q1: VCC and I/O signal

Part Number: SN74LVC1T45-Q1

Hi Team,

When VCCB is on and VCCA is off, if signal input to VCCA side I/O A, is there any problem?
When both VCCA and VCCB is on, if VCCA=1.8V while 3.3V signal input to VCCA side I/O A, is there any problem?

Beat Regards,
Tom Liu