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TXB0104: TXS0104 vs TXB0104: Push-Pull versus Open-Drain Support furthr question (other thread locked)

Part Number: TXB0104
Other Parts Discussed in Thread: TXS0104E, LSF0204

Would this device work ok as I2C buffer if we use a 1K pullup on the I"C bus - as this will dominate over the 4K pulldown ?