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TXB0101:負荷側の制限

Part Number: TXB0101
Other Parts Discussed in Thread: TXU0101, SN74LXC1T45

VCCA=3.3V, VCCB=5V, OE=3.3V. A 50kΩ pull-down resistor is connected to A of TXB0101. 3.3V system is connected to CPU. The speed is 100kHz. It will not work if connected to a 5V circuit. (Works even if the 5V circuit is not connected). What could be the possible causes?