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SN74AVC4T245: VCCA Clarification

Part Number: SN74AVC4T245

Tool/software:

Hi,

I have a customer who is using the 74AVC4T245 device and had a clarification question about a line in the data sheet. When it says "I/Os Are 4.6-V Tolerant”, is this true even when Vcca is 0V?