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SN74LVC16T245: Resistance Testing

Part Number: SN74LVC16T245

Hello,

The following circuit has the path from C1 to J1 as a multi-layer flex circuit. Assume the flex has been damaged with possible shorts. C1 is not accessible. Readings can be taken only from the J1 side.

Is it possible to arbitrarily take a resistance reading from any J1 point to any other J1 point without damaging U1? What cautions should be observed?

Thank you,

Victor