TXS0102: Some questions

Section 4 of the application report A Guide to Voltage Translation With TXS-Type Translators (SCEA044) says:

There is a tradeoff between achieving a maximum data rate and driving heavy capacitive loads simultaneously. With heavy capacitive loads, the one-shot can time-out before the signal is driven fully to the positive rail. In this scenario, only the pull-up resistors will pull the line high in accordance with its RC time-constant determined by the resistive and capacitive loadings. It is best to avoid this condition by driving capacitive loads less than 70pF when maximum data rate are desired. With capacitive loading >70pF, the TXS-type devices will still successfully operate at lower data rates.

Please note that maximum data rate that the TXS can achieve with 70 pF is 2 Mbit/s. The I²C specification limits fast-mode speed to 400 bit/s, with a maximum bus capacitance of 400 pF; this should work fine.