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SN74LVC2T45: Is the partial-power-down mode safe for long duration use?

Part Number: SN74LVC2T45


The datasheet specifies a partial-power-down mode that activates whenever one of the supplies is powered up, and the other supply is powered down. I would like to power down VCCB, while keeping VCCA and the inputs powered up. This will be the condition for 99% of operation, and up to 6 seconds at a time. Is this partial-power-down mode safe for high duty cycles and long duration use?