Should one output of the TXS0108E only have one I2C device connected to it?
P.S: I have some boards with several I2C different devices. I just happen to notice that when VccB (5V) is connected and VccA left open the I2C devices just works fine. The I2C devices Vcc's are connected to VccB (5V) The 5V, 3.3V, SDA, GND and SCL are from an RPI3 in this case. Of-course in the final design VccA will be connected (3.3v) though curious why this is and if this makes sense and is normal behavior.