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SN74LVC2G17-Q1: Shutdown

Part Number: SN74LVC2G17-Q1

Hello, 

I have a customer who is working with this buffer in the entrance of his system, 

The system is sometimes turned off meaning the buffer doesn't receive voltage, 

The second system sends signals to the first system(while first system is shutdown), is there an issue in this situation?

If there is, is there a different buffer that can work in this situation?

Thanks, 

VL