I am using an ADC channel of the LM4F232H5QC to measure the output of a high gain current to voltage convertor (OPA129 op amp with 100Mohm gain). When I run the circuit using a bench top power supply, I get good readings with a noise floor of 20 ADC counts, which I am happy with. When I run the circuit using an isolated plug in wall adaptor I get a D.C offset in the ADC readings with the noise floor increasing to around 120 ADC counts.
If I connect the ground clip of an oscilliscope to the circuit ground (plug in power supply negative), the offset is removed, so I can't actually probe the circuit without affecting the problem. The circuit is on a 4 layer board with a power and ground planes, the plug in power supply is supplying a 5V and 3.3V linear regulator (TPS71550 and TPS71533) and the power supplies, op amp and microcontroller have decoupling capacitors as recommended by their associated datasheets. It seems there is still some ground loop somewhere. I think since the op amp is such high gain any small offsets associated with its inputs might be the cause of the problem and was thinking that perhaps using the ADC in differential input mode might be a way forward. I would be interested to hear any thoughts on this approach and any alternative.