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RM48L950: Strange behavior when in system mode after initializing MPU

Part Number: RM48L950

I am experimenting with the use of the MPU and have found strange behavior after configuring the MPU but in system mode. From reading the datasheets, I have not found any help, although I may be missing something. I have found that being in system mode after initializing the MPU causes some parts of my code to not work. Specifically, serial printing does not seem to transmit anything and one of my timer interrupts don't seem to fire. Is this an expected side effect of the MPU while in system mode?

I am currently only defining a background region starting at address 0 and 4GB in size. The memory type and permission is MPU_NORMAL_OINC_NONSHARED and MPU_PRIV_RW_USER_RW_EXEC respectively.

Thanks