We have occasionally been seeing the issue where our BQ27621 inadvertently enters shutdown mode. I confirmed this by measuring 0 V on VDD, and that toggling GPOUT seems to resolve. This TI response on E2E indicates this is a known issue which can be caused by ESD, too fast I2C transactions, etc.
However, there is also another thread where TI representative states that the LDO output (VDD) needs a 4.7 uF cap (as opposed to 0.47 uF mentioned in the datasheet). Could you clarify what cap. you recommend on VDD? And may this help reduce the number of shutdown-issues we are seeing?
Our schematic: