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AM6442: AM6442BSEFHAALV :UART TX issue

Part Number: AM6442

Tool/software:

Hi team 

We are using UART5 for connecting with a USB to UART connector , but getting PMIC issue (PMIC not turned on )  when TX is connected  . In our design it is a direct connection , no level translator or isolator is used in the lines . We noticed in ,most of the reference designs level shifter is used in UART lines . Is it mandatory to use level shifter or isolator for UART interface ?