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AM3352: DDR3 routing

Part Number: AM3352


Hello,

As we are following 50Ohm impedance in single ended signals and 100Ohm impedance differential signals in routing. 

My question is in routing differential like Clock+ and Clock- we follow 100Ohm differential impedance. Is it necessary to follow 50Ohm for individual signals? Means we need to follow 50Ohm for Clock+ and 50Ohm for Clock-??? 

55Ohm for Clock+ and 45Ohm for clock- can work??? 

Regards

Dharit