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Customized DM648 + Performance Degradation

Other Parts Discussed in Thread: MSP430F169

hello all

I have customized my DM648 prototype board.

The PCB is completely copy of Lyrtech schematics, that covers the Ethernet switch subsystem.

I have burned the original MSP430F169  in my customized board.

My customized works well for 4hrs , after which i see performance degradation . Like the no transfered packets decrease.

Can experts help as to what mayb the source of performance degradation ? 

Can it be a PCB problem ? as my customized board has 12layers 

kindly plz help in narrowing down the problem

Regards