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Seeking High Current DC to DC Converter Design

I need to design a high current DC to DC converter, with the following parameters:

1.  Input voltage range:  12VDC to 80VDC.

2.  Constant Output voltage: 50.2 VDC (alternatively, any voltage between 48 and 51 constant VDC).

3.  Current output:  around 40A. at 12 VDC, and ramping up to 150 A. at 40 VDC and above.

Any guidelines and advice on how to go about the design and which components to use would be appreciated.