Because of the holidays, TI E2E™ design support forum responses will be delayed from Dec. 25 through Jan. 2. Thank you for your patience.

This thread has been locked.

If you have a related question, please click the "Ask a related question" button in the top right corner. The newly created question will be automatically linked to this question.

Need Help in finding a Suitable OpAMP for EEG active sensor Electrode design

Other Parts Discussed in Thread: ADS1299, OPA376, TLV376, OPA387, OPA391, OPA397, OPA392

Hello,

we are working on product development of EEG device. we have choosen ADS1299 for the front end EEG capture. right now we have to design an active electrode for EEG, in which we are going to use DRY electrodes, so have Active electrode is best option. for that, we were unable to find any reference designs. could you please suggest us the best and available opamp parts for using in the design which ever is compatible with the input of the ADS1299 . we are bit confused like whether we should use precision amplifiers/general opamps or instrumentation opamps.which should be considered for this application.  we might need a very lower offset, high CMMR, low noise ampliers which can work using -2.5 to +2.5 Dual polarity supply. please suggest us part numbers and if any reference designs available for active eeg electrode please share it. and more over the size should be smaller as possible as entire active electrode circuit has to be fit in a <10mm dia PCB. Thank you

with regards

Dr.N.Chandra Sekhar,phd

  • Hi Chandra,

    because of the absence of conducting gel, dry electrodes are considerably higher ohmic than wet electrodes. The equivalent circuit of a dry electrode is a high resistance (10k...100k ?) in parallel with a high capacitance (10n...100n ?), with highly varying values from electrode to electrode. So, in order to get a high common mode rejection, the input impedance of preamp of active electrode should be extremely high in the signal frequency range. Take an OPAmp with JFET or CMOS input stages. (This also minimizes the risk of suffering from popcorn noise.) Take an OPAmp with extremely low common mode input capacitance. Every pF counts! And avoid additional capacitances in the input filtering. Only use a current limiting resistor at the input of OPAmp. Use an input diode clamp only, if at all, in combination with low junction capacitance diodes showing ultra low leakage current.

    For lowest noise take an OPAmp showing not only low input voltage noise but also low input current noise. Remember, the electrode impedances are very high at low frequencies. Look for low noise OPAmp especially at the very low frequencies! An OPAmp with low noise at 10kHz but high noise at 100Hz is not what you should search for. But look for an OPAmp with very low noise at the lowest frequencies.

    And, important: Do only use batteries for the powering of electronics being in direct contact to the patient. Use safe galvanic isolation when connecting the front-end electronics to mains powered equipement !!!!!!!

    Kai

  • Hi sir,

    Thank you very much for a detailed reply. yes device is powered by battery. sir, it would be great , if you can able to filter out some specific part numbers to start with. bcz many parameters, leading to so much confusing. also in pure analog electronics design, our expertise is limited. so if you can get your help and any reference designs, it would be good. also in which configuration it needs to be wired? 

    can we use an instrumentation amplifier for this purpose?  

    Thank you

    chandra

  • Hi Chendra,

    this depends on how you intend to arrange the electrodes. There are several options.

    The highest common mode rejection can be achieved by a pre-amp which only works as a buffer with a gain of 1. The common mode rejection via instrumentation amplifier is done in a second step, where the signals of two adjacent channels are subtracted from each other in an instrumentation amplifier. This offers the best common mode rejection, because there are no gain setting resistors with their manufacturing tolerances and drifts. Another advantage is the absence of input cable with its additional and unpredictable stray capacitance. And the output cable can be driven very low ohmically, keeping the common mode rejection high. In this case a standard OPAmp could be used in the pre-amp.

    Is this what you plan?

    Kai

  • The OPA376 is often used for such applications.

    Kai

  • Hi Dr. N. Chandra,

    Thanks for your post. I can help you.

    Please view this training video: https://training.ti.com/designing-signal-conditioning-circuits-single-lead-electrocardiogram-ecg?context=1148465-1148591

    Dry electrodes are discussed at 1:50. Kai is correct, OPA376 / TLV376 are common choices for amplifiers. 

  • Hi kai, & tamara,

    thanks for your valuable input. in datasheets of OPA376 & TLV376 its mentioned as single supply voltage.. but in specs its mentioned -+2.75 max.. can i hook up these between -2.5V for -vs and +2.5 for  +Vs? 

    also in order to configure it as unity gain buffer, just hookup the V+ to dry electrode, and v- to the output. is there any power supply capacitors or any other capacitances needed in input /output. I think we may need to use ESD protection diodes for input and oputput. in that case do i need to wire the GND also? Does other components on input and output creates any disturbance on the signals..?

    the Drive voltage will be the Bias output from the ADS1299 .. do i need to reference this voltage in the buffer preamplifier stage? if so how?

    sorry for my so basic questions, just like to know more in details, before we proceed to test in real. Thank you

  • Hi Dr. Chandra,

    Happy to help you!

    You can use dual-supplies like -2.5V to +2.5V on the OPA376 / TLV376. 

    Noise can propagate into analog circuitry through the power pins of the circuit as a whole, and the op amp itself. Bypass capacitors can reduce the coupled noise by providing low-impedance power sources local to the analog circuitry. You may connect low-ESR, 0.1-µF ceramic bypass capacitors between each supply pin and ground, placed as close to the device as possible.

    In the same video I linked above, you may refer to time 3:38 for a sample circuit with the drive amplifier. The output of the AD1299 would feed into this amplifier. 

  • Hi Chandra,

    the "right leg" thingy is always used in ECG amplifiers. In EEG amplifiers, on the other hand, it can be seen sometimes, that the usual "right leg" connection is omitted and that one electrode on the head is connected to signal ground, instead. Or by other words, if you have "n" electrodes on your head, the signals of "n-1" electrodes are actively amplified and one of the electrodes is connected to signal ground. This method shall guarantee that the common mode volltage of the actively amplified electrodes does not move all too far away from signal ground.

    One additional hint: A 10...20R isolation resistor at the output of OPA376 should be added to ensure stability, if a cable is connected to the output of OPAmp. See section 7.3.3 and figure 22 of datasheet of OPA376.

    Kai

  • Hi sir,

    Thanks you for your help, seems like with the provided information, i might able to start designing, but sadly OPA376 seems out of stock, not even available any where. can OPA387 be used, seems like it has still lower offset level. but even that is out of stock. any alternatives?

  • Hi Chandra,

    chopper OPAmps should not be used here, because they tend to be very noisy with the very high source impedance of active electrodes. So I would not take the OPA387.

    Many other OPAmps can be used instead of OPA376, but most of them are more noisy. The OPA391 might be a good candidate, because of very low input offset voltage and ultra low input capacitance. Unfortunately, the noise is higher compared to the OPA376.

    Maybe Tamara can help with alternatives?

    Kai

  • Hi Dr. Chandra,

    You may consider sampling / testing the TLV376: https://www.ti.com/product/TLV376#order-quality 

    This is the slightly relax-spec version of the OPA376 and would be a good alternative. 

  • Hi Tamara & kai,

    Thank you. but TLV376 seems to have higher offset around 100micro volt. will that be fine for a EEG application where it demands for lowest offset.THank you

  • Hi Tamara & kai,

    i found OPA392 & OPA397 parts available in stock from mouser, can these parts fit in place of OPA376.THank you

  • Hi Dr. Chandra,

    Yes, you may use the OPA392 or OPA397 as an alternative solution to the OPA376.