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TLC4502: Unable to record sensor response

Part Number: TLC4502
Other Parts Discussed in Thread: LMP7721

Dear Team -

We built a pH circuit leveraging TLC 4502 op amplifier in line with the attached schematic. We tested the circuit with the help of a PPS and the value_out is recorded perfectly.

But when we connect a pH sensor we are not getting desired value instead the value_out is either staying constant or too low.

  1. Can someone help us to understand what where might are we missing?
  2. Additionally, point out mandatory items that are to be taken care of during the PCB design in such cases?