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TLV4333: ESD protection and risk

Part Number: TLV4333
Other Parts Discussed in Thread: AMP-PDK-EVM

Tool/software:

Hello, 

I have a generic question about the ESD protection. I notice that the valuation module AMP-PDK-EVM, which is sandbox for engineers to abuse. it doesn't have any ESD protection on the board. I have noticed that the data sheet of TLV4333 claims 4000V HBM, 1000V CDM.  when I use this chip in a product, a standard industry application. in a closed chassis, not use accessible. is it necessary to protect all IO pins of this chip. how to evaluate the risk of using a TVS or not? 

is there a rule of thumb to use an ESD in a system. any suggestion is appreciate.

Best Regards,

David