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Ryuji,
1. It is possible to leave these pins disconnected but they may possibly be disturbed by capacitive coupling from nearby signals.
2. If E/D com is connected to V-, it will not be affected by capacitive coupling from nearby signals. This does not change the possibility of coupling to the E/D pin. It could still be be sensitive to capacitive coupling.
3. If you do not use the status flag it can be left disconnected. The status flag is an open-drain output.
Regards, Bruce