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INA333: Input Bias Current Problem

Part Number: INA333
Other Parts Discussed in Thread: OPA333, OPA330

Hi all,

Recently I have been debugging my circuit which is meant to amplify EEG signals from mice,

but I have encountered a problem with the INA333 chip (used as the first stage amplifier in a two stage amplifier design) that I can't seem to be able to fix so 

would really appreciate if I can get some help.

Below is the schematic for the first stage of the AFE part of the circuit.

Model in TINA and simulation result when using a  sine wave signal of 10mVpp at 100Hz:

The gain of the circuit is 100 and the INA333 is biased at half supply at 1.4V (Vref).

The AC response: 

BandPass 0.005 to 200Hz ( overall the system system should be a 4th order bandpass from 0.01 to 150Hz so the first stage is designed to take into account the shift in cutoff frequencies due to cascading)

However when I test this circuit in the lab I do not get the same result.  Instead of the output swinging from 0.9 to 1.9 I  (centered at 1.4V) I get an output that goes from 

0V to around 300mV.  And this is due to the presence of  a negative DC offset of around -16mV between the inputs.  

Since then I have been been trying to work out what was causing this DC offset and I think it is due to the input bias current not having a return path due to 

the resistors R4,R5 being too large. The reason I suspect this is as soon as I add resistors of 100K in parallel to them I get the output to be similar to the simulation result.

If I add the resistor only to R4 then the output goes to ground in a couple of seconds which I am taking it to be due to the accumulation of charges at the negative input.

If I add the resistor only to R5 then the output goes to positive rail in a couple of seconds which I am taking it to be due to the accumulation of charges at the positive input. 

I was told that the offset could be due to the resistance of the capacitors C2 and C3 forming a voltage divider with R4 and R5, so I removed capacitors C2, C3 and C1 as well for good measure. But that did not affect the output.  

After that I removed capacitors C4 and C5 and let Vref to be the input to both inputs of the amplifier, even that did not affect the output( ie it was still 0 to 300mV), it was only when I reduced the resistance of R4 and R5 (ie adding parallel resistors to them) the output became similar to the stimulation result. 

So my problem is this, is 10Meg too large as the datasheet specifies a max DC biasing current of only 200pA. How do I calculate the maximum resistance allowed?. An easy solution to this problem would to reduce the resistance however this would reduce the input impedance of the circuit and I need the input impedance to be 1Meg or preferably 10Meg as the source impedance is quite high. So it there a better solution to this problem?

Sorry if the problem seems trivial as I am quite new to circuit design so I would really appreciate any help.

Thanks in advance!

  • Hi Bryan,

    It definitely sounds like you have a bias current issue. Unfortunately I do not believe there is a hard rule on how to size the resistors, but 10MOhms definitely appears to be too large. How large is your source impedance? It sounds like you may need to buffer the output of your source so you can drive the INA with a low impedance source and thus use smaller resistors. In fact, given that you are inputting a single ended signal, I believe it may be easier for you to eliminate the INA altogether and just use an op amp like the OPA333.

    Regards,
    Zak Kaye
  • To Zak,

    Hi thank you for your prompt reponse.  I do not have a hard figure for the source impedance but I have been told that it is a region of 100K to 1Meg depending on how well the contact is. The reason I had doubts about it being a input biasing current problem because after removing capacitors C4 and C5 the problem stillpersisted, but I guess saturation was due to stray capacitances?  The reason for using INA333 is because I am using bipolar measurement, so both signal and reference are fed into the amplifier,  in the simulation I have the reference input tied to gnd. 

    My second stage amplifier is a 3rd order AC coupled low pass sallen key amplfier based on OPA330 with a gain of 2,  the DC return resistors are also 10Meg but it seems to be working really well. And if I remember correctly OPA330 has similar biasing current to INA333. If I have to reduce the impedance at INA333 and buffer the inputs maybe I can replace it with a differential amplifier based on OPA330 but with 10M return resistors?  Do you think this will work and also is it possible to simulate the biasing current problem in TINA?. 

    Thank you so much for your help.

    Regards,

    Bryan Hsieh