There are various INA21xA/B/C devices. Why are the trailing letters different?
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The trailing letters refer to device versions where transient robustness and ESD Ratings have changed.
If you are creating a new design, we recommend you use the INA21xB or INA21xC devices.
The B and C versions of the device have a different ESD cell than the A version. The C version has better gain error than the A or B versions.
Please see this thread for further explanation.
Also, see TIDA-00302 for more information about using passive components to protect against transients on current sense amplifiers.