It is not recommended to use the INA250 for inline current measurements with PWM inputs. Please look into the INA240 and especially the INA253 for this kind of application.
A fast-edge pulse, while not damaging to the device, will cause the input ESD cells to turn on very briefly. A very small amount of heat is generated through the ESD cell. Normally this is fine but providing sustained, high frequency pulses from a PWM will cause the part to heat up over time. Filtering the signal at the inputs of the INA will slow the edges down and provide better operating conditions.
Related E2E threads:
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