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pre amp -in +in connections

Other Parts Discussed in Thread: OPA454, OPA549

Can a amplifier speaker wire be ran to +in and -IN on this chip and apmlify it out to 100 volts for an amplifier 

Attempting build amp off speaker wire signal line extra 40 to 50 watts

Also to keep on Should I jump enable to enable making that circuit closed to keep running ?

OPA454AIDDAG4