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ADS1298: The performance difference between the internal reference and an external reference

Part Number: ADS1298
Other Parts Discussed in Thread: OPA350, REF5025

Hi, Team, hope everything goes well with you all~

My question is about the performance differences between the internal reference and an external reference when deploying the ADS129x series-based system, ADS1298 for instance.

Currently, optimal system performance is crucial for our application scenarios. After checking the related description in the ADS1298 datasheet, we found there are not too many details about the reference voltage, such as noise level and stability, etc., and this datasheet just proposes an example based on REF5025 and OPA350 solution. My question is if an external reference will perform better than the internal reference in terms of the collected signal quality, such as ECG measurement? In addition, is there any guidance document when using an external reference?

Meanwhile, if a multi-channel system, which means more than one chip will be used, is designed and how to determine how many reference chips will be needed given the driven capability and noise issue?

Looking forward to your reply, and thanks ahead for the help from our community!

Zeyu