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TCA39306: In Translation configuration. EN pin was controlled by GPIO

Part Number: TCA39306

Hi,

I am using the TCA39306 as an I2C translator. In the datasheet, I see the translation configuration where Vref2 > Vref1 + 0.7V used EN pin connect with Vref2.

So, I have a question, In this case, I want to control EN pin by GPIO it's correct or not? or any potential issue? as attached image.

Regards,

Ve Phan