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Based on the datasheet for SN65HVD50, the receiver and driver circuits seem independent of each other.
I don't see any reason this would be an issue, but want to double check before we order PCBs.
Low frequency (100Hz - 360Hz).
8 microsecond pulse (+/-1 microsec tolerance for both width and timing)
Yes, the circuits are independent. A full-duplex transceiver can be used as a buffer.
The SN65HVD52 is optimized for lower speeds.