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TMUXHS221: Cascade connection

Part Number: TMUXHS221

Tool/software:

Hello,

I would like to confirm whether following configuration is available or not.
My question is similar to following thread, but we consider to use 2 cascade pattern.
https://e2e.ti.com/support/interface-group/interface/f/interface-forum/553265/can-we-multiplex-a-usb-signal-to-20-usb-devices-using-1x2-multiplexer-by-cascading

* Connect two TMUXHS221 in series.

I believe that concern is only signal integrity (from viewpoint of eye pattern), however if you have any concern about this under USB2.0 specification, could you please tell it to me ?

Best Regards,