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TCA6416A: Unused PIN in Standby Mode

Part Number: TCA6416A

Tool/software:

Hi,

Although it is rare, when the TCA6416A is in standby mode on a mass-produced board, the current consumption can be around 100 to 200uA.
Looking at the circuit diagram, some of the ports are unused and OPEN.
I don't think there's a problem if they're set as output.
When an I/O port is set as input, normally pull-up or some other processing is required, but are there any concerns about leakage current or unintended operation if the port is OPEN even in standby mode?

Best regards,
Hiroshi