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SN74AXC8T245: Open on one of channel A of SN74AXC8T245

Part Number: SN74AXC8T245
Other Parts Discussed in Thread: SN74GTL2014, LSF0108

Hi, 

What would happen if one of channel A of  SN74AXC8T245 is open while others are configured its direction ?

Any leakage would happen and any prevention action to be taken ?

Thanks