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TMS570LC4357-EP:What is the principle behind FLASH OTP region one-time programming?

Part Number: TMS570LC4357-EP
Other Parts Discussed in Thread: TMS570LC4357

Tool/software:

Dear TI Team

What is the principle behind the one-time programming of the FLASH OTP area of the TMS570LC4357 chip? Is it software protection or hardware-level design that ensures this?