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18-bit LVDS panel on 24-bit framebuffer

For an 18-bit LCD, I knew that we can use the 24-bit connections and connect the highest 6 bits for each color. Now, I have an 18-bit LVDS panel and my hardware design is 24-bit. It looks the highest two bits are wiped out. Do you have any suggestions?Is it possible to work around it from software?