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About the difference in the voltage between GND1 and GND2 of ISO7640FM

Other Parts Discussed in Thread: ISO7640FM, ISO7341C, ISO7342C, ISO7641FC, ISO7842

Our customer has questions about ISO7640FM.
I'm posting the questions for the customer:

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About ISO7640FM;

(1)
I am examining the circuit that the difference in the voltage
between GND1 and GND2 of ISO7640FM will always be 5 volts.

Does such usage become a problem?

Please let me know the specifications about DC voltage difference between GND1 and GND2.

(2)
Could you give me the detailed information about the following application?

At the bottom of page 16 of the ISO7640FM data sheet which suggests:
"For applications that require DC working voltages between GND1 and GND2,
please contact Texas Instruments for further details."

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thanks in advance