We are Using the Below Configuration as Transimpedance Amplifer with Following Parameters
Please refer to schematics Attached:- Circuit Portion 1
1)IS1OUT- Output from Nanosensor Which is in the range of 0nA to 10uA
2) U6 Output converts the IS1Out to Voltage and compared with Vref=5V.
3)This circuit being NIV Transimpedance amplifier initially output is 5V at IS1out=0nA and Decreases with a resolution of 1mV based on raise of IS1out. Range is 0 to 5uA.
4)Load for U6 is Circuit Portion 2
Problem Seen
1)If Vref is above 3.3V in the circuit attached for temperatures in the range of 25 to 45C the Output reaches 0 and recovers back when temperature is reduced to 25C .
2)Attached is typical data log for Reference.
Can we get a feedback on what would be the cause of the Problem seen??
Note: 2 Attachments Schematics in word doc file and data log in Excel fileTIA Chamber Test Data.xlsxTI_Schematics_June26-2019.docx

