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ADS1293: ADS129X : Setting Common-Mode With and Without RLD electrode.

Part Number: ADS1293
Other Parts Discussed in Thread: ADS1298,

Hi! I am working with biosignals (EMG and EEG) and I have some questions about the use of ads129X IC in a PCB project. I am familiar with ads1293 but my questions may apply to the ads1298. I am trying to understand the differences in two methods reported in datasheets of ADS devices. Here is a print about what I am talking about. (The print is from ads1298 datasheet)

Seems to me that the second strategy is applied to remove de DC offset but presents poorer performance regarding reducing the noise of the signals. Can someone explains to me when I should use each of the approaches? And what about using the two approaches at the same time? Is it redundant and they might compete for driving the common-mode? 

And another topic is patient safety. Any of those approaches is better regarding safety? Are there any TI's Application Note regarding safety for patients?

Best.